Novel Therapeutic Effects of Leonurine On Ischemic Stroke: New Mechanisms of BBB Integrity

Figure 4

SCM-198 protected against ischemia-like injury in the in vitro BBB model. bEnd.3 cell line was exposed to 6 h of OGD followed by 4 h reperfusion after treated with different concentrations of SCM-198. (a) OGD/R markedly increased cell death, SCM-198 dose-dependently improved the cell viability, F (3, 14) = 12.57, . (b) SCM-198 reduced the LDH leakage in the supernatant after OGD/R, F (3, 4) = 39.25, . (c) The fluorescence intensity of intracellular ROS, F (4, 12) = 43.35, . (d) OGD/R produced abundant ROS in the cells, while SCM-198 significantly reduced the ROS formation, scale bar = 10 μm. Values are expressed as mean ± SEM. ^# versus the control group, versus the OGD group, .

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