Research Progress on Signaling Pathway-Associated Oxidative Stress in Endothelial Cells

Figure 1

Schematic diagram of Nrf2/ARE pathway. The → indicates activation or induction. Under oxidative stress conditions, Nrf2 is separated from Keap1 in the cytoplasm and after linking with ARE is transferred to the nucleus. Then, the expression level and the amount of antioxidative enzymes regulated by Nrf2 increases and the damage caused by the imbalance of the redox potential are attenuated.