Mitochondrial Uncoupler Prodrug of 2,4-Dinitrophenol, MP201, Prevents Neuronal Damage and Preserves Vision in Experimental Optic Neuritis

Figure 2

MP201 treatment attenuates RGC loss. Neuroprotective effects of MP201 were evaluated by counting RGCs immunolabelled with Brn3a antibody in 12 standardized fields, three from each quadrant of the retina. (a) RGC loss in eyes of EAE mice ( versus control, ) is reduced by 16 mg/kg MP201 treatment from days 15 to 42 (@@@ versus EAE, ). 80 mg/kg MP201 also induces a significant (@ versus EAE, ) improvement in RGC numbers. (b) Representative images show RGCs in one field of retina from each group (original magnification ×20).

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