Metformin and Its Sulfenamide Prodrugs Inhibit Human Cholinesterase Activity

Figure 3

The effects of metformin and phenformin (a) and prodrugs 1, 2, and 3 (b) on BuChE reaction velocity. The velocity of pure BuChE was 0.160 A/min (grey line). The results are presented as a mean of three independent experiments. Phenformin and prodrugs 1, 2, and 3 inhibited the reaction depending on their concentration.

(a)

(b)