Metformin and Its Sulfenamide Prodrugs Inhibit Human Cholinesterase Activity

Figure 4

Hanes-Woolf’s curves. (a) AChE and metformin at concentration of 2.35 μmol/mL (IC₅₀), mixed-type inhibition; (b) AChE and prodrug 1 at concentration of 0.89 μmol/mL (IC₅₀), noncompetitive inhibition; (c) BuChE and prodrug 1 at concentration of 0.028 μmol/mL (IC₅₀), mixed-type inhibition.

(a)

(b)

(c)