Chronic Variable Stress Is Responsible for Lipid and DNA Oxidative Disorders and Activation of Oxidative Stress Response Genes in the Brain of Rats

Table 1

Stressor agents used during the chronic variable stress.

Day of treatment	Stressor	Duration	Start time
1	Water deprivation	24 h	8:00 a.m.
2	Food deprivation	24 h	9:00 a.m.
3	Isolation	24 h	10:00 a.m.
4	Isolation	24 h	10:00 a.m.
5	Isolation	24 h	10:00 a.m.
6	Flashing light	3 h	12:00 a.m.
7	Food deprivation	24 h	8:00 a.m.
8	Forced swimming	10 min	9:00 a.m.
9	Restraint	1 h	11:00 a.m.
10	Water deprivation	24 h	9:00 a.m.
11	No stressor	—	—
12	No stressor	—	—
13	Restraint and cold	2 h	10:00 a.m.
14	Flashing light	2.5 h	9:00 a.m.
15	Food deprivation	24 h	8:00 a.m.
16	Forced swimming	15 min	12:00 a.m.
17	Isolation	24 h	8:00 a.m.
18	Isolation	24 h	8:00 a.m.
19	Isolation	24 h	8:00 a.m.
20	Water deprivation	24 h	10:00 a.m.
21	Food deprivation	24 h	9:00 a.m.
22	Flashing light	3 h	13:00 a.m.
23	Restraint	2 h	12:00 a.m.
24	Isolation	24 h	8:00 a.m.
25	Isolation	24 h	8:00 a.m.
26	Restraint and cold	1.5 h	12:00 a.m.
27	Forced swimming	10 min	10:00 a.m.
28	Flashing light	3.5 h	12:00 a.m.
29	No stressor	—	—
30	Food deprivation	24 h	8:00 a.m.
31	Restraint	3 h	9:00 a.m.
32	Flashing light	2 h	10:00 a.m.
33	Water deprivation	24 h	8:00 a.m.
34	Restraint and cold	2 h	10:00 a.m.
35	Forced swimming	15 min	11:00 a.m.
36	Isolation	24 h	8:00 a.m.
37	Isolation	24 h	8:00 a.m.
38	No stressor	—	—
39	Flashing light	3 h	13:00 a.m.
40	Forced swimming	10 min	8:00 a.m.