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Oxidative Medicine and Cellular Longevity
Volume 2017 (2017), Article ID 7340143, 11 pages
Research Article

Antioxidant and Anti-Inflammatory Effects of Shungite against Ultraviolet B Irradiation-Induced Skin Damage in Hairless Mice

1Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon 220-701, Republic of Korea
2Department of Microbiology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon 26426, Republic of Korea
3Department of Internal Medicine, Wonju College of Medicine, Yonsei University, Wonju, Gangwon 26426, Republic of Korea
4Department of Rheumatology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon 26426, Republic of Korea
5Institute for Poverty Alleviation and International Development (IPAID), Yonsei University, Wonju Campus, Wonju, Gangwon 220-710, Republic of Korea

Correspondence should be addressed to Tae-Young Kang; and Kyu-Jae Lee; moc.liamg@9oibdem

Received 3 February 2017; Revised 14 June 2017; Accepted 4 July 2017; Published 13 August 2017

Academic Editor: José L. Quiles

Copyright © 2017 Ma. Easter Joy Sajo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


As fullerene-based compound applications have been rapidly increasing in the health industry, the need of biomedical research is urgently in demand. While shungite is regarded as a natural source of fullerene, it remains poorly documented. Here, we explored the in vivo effects of shungite against ultraviolet B- (UVB-) induced skin damage by investigating the physiological skin parameters, immune-redox profiling, and oxidative stress molecular signaling. Toward this, mice were UVB-irradiated with 0.75 mW/cm2 for two consecutive days. Consecutively, shungite was topically applied on the dorsal side of the mice for 7 days. First, we found significant improvements in the skin parameters of the shungite-treated groups revealed by the reduction in roughness, pigmentation, and wrinkle measurement. Second, the immunokine profiling in mouse serum and skin lysates showed a reduction in the proinflammatory response in the shungite-treated groups. Accordingly, the redox profile of shungite-treated groups showed counterbalance of ROS/RNS and superoxide levels in serum and skin lysates. Last, we have confirmed the involvement of Nrf2- and MAPK-mediated oxidative stress pathways in the antioxidant mechanism of shungite. Collectively, the results clearly show that shungite has an antioxidant and anti-inflammatory action against UVB-induced skin damage in hairless mice.