The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages

Figure 1

The LGM2605 pretreatment regimen used in this study. Macrophages subjected to asbestos exposure with or without LGM2605. Elicited murine peritoneal macrophages were exposed to 50 μM LGM2605 4 hours prior to exposure to crocidolite asbestos fibers (20 μg/cm²). Culture medium and cells were harvested at 0, 0.5, 1, 2, 4, 6, 8, 10, 12, and 24 hours post asbestos exposure.