Caveolin-1: An Oxidative Stress-Related Target for Cancer Prevention

Figure 4

Cav-1 is an oxidative stress-related protein. On one hand, reactive species could decrease Cav-1 expression and induce its degradation through the proteasome pathway. On the other hand, reactive species could induce the phosphorylation but inhibit the palmitoylation of Cav-1. In addition, reactive species could induce Cav-1 internalization and inhibit the trafficking of newly synthesized Cav-1 to membrane raft domains.