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Oxidative Medicine and Cellular Longevity
Volume 2017 (2017), Article ID 7478523, 13 pages
Review Article

Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant

School of Chinese Medicine, The University of Hong Kong, Pokfulam, Hong Kong

Correspondence should be addressed to Yibin Feng; kh.ukh@gnefy

Received 28 June 2017; Revised 28 October 2017; Accepted 5 November 2017; Published 26 December 2017

Academic Editor: Rodrigo Valenzuela

Copyright © 2017 Ning Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Selenium is an essential mineral naturally found in soil, water, and some of the food. As an antioxidant, it is one of the necessary trace elements in human body and has been suggested as a dietary supplement for health benefit. Although the human body only needs a trace amount of selenium every day, plenty of recent studies have revealed that selenium is indispensable for maintaining normal functions of metabolism. In this study, we reviewed the antioxidant role of nutritional supplementation of selenium in the management of major chronic metabolic disorders, including hyperlipidaemia, hyperglycaemia, and hyperphenylalaninemia. Clinical significance of selenium deficiency in chronic metabolic diseases was elaborated, while clinical and experimental observations of dietary supplementation of selenium in treating chronic metabolic diseases, such as diabetes, arteriosclerosis, and phenylketonuria, were summarized. Toxicity and recommended dose of selenium were discussed. The mechanism of action was also proposed via inspecting the interaction of molecular networks and predicting target protein such as xanthine dehydrogenase in various diseases. Future direction in studying the role of selenium in metabolic disorders was also highlighted. In conclusion, highlighting the beneficial role of selenium in this review would advance our knowledge of the dietary management of chronic metabolic diseases.