Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells

Figure 1

Signaling pathways of Sirt1 inhibiting reactive stress in ECs. There is interplay between Sirt1 and FOXOs in ROS reduction. Sirt1 also directly interacts with eNOs and SOD, which could be regulated through FOXOs. NOX and NF-κB also serve as downstream target of Sirt1, which could be downregulated by NF-κB activation. These molecules play pivotal roles in reactive stress resistance in ECs.