Acarbose Accelerates Wound Healing via Akt/eNOS Signaling in db/db Mice
Acarbose therapy accelerated wound closure and enhanced angiogenesis in db/db mice. An approximate 6 mm diameter circle wound was made by punch biopsy on dorsal and wound healing was assessed every 2 days until day 14. (a) Acarbose treatment obviously accelerated wound closure in db/db mice compared to untreated diabetic ones. (b) Acarbose treatment significantly increased wound capillaries compared with the untreated db/db mice on days 7 and 14. (c) Typical photographs of CD31 staining on days 7 and 14; red arrows point to CD31-positive capillaries; boxed regions (100x; scale bar = 100 μm) are shown at higher magnification (200x; scale bar = 50 μm) to the right. , , and versus Con; , versus db/db. (d) SDF-1α expression in wound site was present predominantly in acarbose-treated group on day 7; red arrows show positive brown staining for SDF-1α; scale bar = 50 μm. Values are expressed as the mean ± standard deviation ( per group). Con, control; Aca, acarbose.
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