Exercise Combined with Rhodiola sacra Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise-Induced Muscle Damage through Enhancement of Mitochondrial Quality Control

Figure 11

Schematic diagram of the putative mechanism by which aerobic exercise and Rhodiola sacra, alone and combined, improve exercise capacity and ameliorate muscle damage induced by exhaustive exercise in mice: Aerobic exercise and Rhodiola sacra, alone and combined, enhanced mitochondrial quality control, including mitophagy, mitochondrial dynamics, and biogenesis, in SCM of mice. These effects contribute to the enhancement of mitochondrial function and exercise capacity and protection against SCM damage caused by excessive mitochondrial oxidative stress resulting from EE.