Mitochondrial Nucleoid: Shield and Switch of the Mitochondrial Genome

Figure 5

Spatial organization of nucleoid-associated proteins. Some proteins that exhibit mtDNA-binding capacity are located in the core region, whereas others might interact with proteins in the core region or other mitochondrial proteins. ANT, adenine nucleotide translocator; ATAD3, ATPase family AAA-domain-containing protein 3; HSP60, heat-shock protein 60; LONP1, mitochondrial AAA protease; mAAA, mitochondrial ATPase-associated with various cellular activities (AAA+) protease; mtDNA; mitochondrial DNA; mtSSB, mitochondrial single-stranded DNA-binding protein; mTERF, mitochondrial transcription termination factor; PHB; prohibitin; POLG, mitochondrial polymerase γ; POLRMT, mitochondrial RNA polymerase; TFB1M, mitochondrial transcription factor B1; TFB2M, mitochondrial transcription factor B2.