|
| Study (years) | Species (sex, n = experimental/control group) | Weight | Model (method) | Time drug given | Anesthetic | Treatment group and administration methods | Control group | Angiogenesis outcome index | Intergroup differences (time) | Secondary outcome | Intergroup differences | Side effect |
|
| Chao et al. [25] | Male Sprague Dawley rats (8/8) | 200–220 g | AMI | 1 day after the surgery | Chloral hydrate [0.3 g/kg, (i.p.)] | Salvianolic acid B 24 mg/kg·4 h, i.v. | Normal saline | (1) VEGF | (1) ; 8 h | (1) Myocardial infarct size | (1) ; 8 h | No report |
|
| He et al. [26] | Male Sprague Dawley rats (15/15) | 200–220 g | AMI | 24 h after the surgery | Urethane [1.2 g/kg, intraperitoneally (i.p.)] | Salvianolic acid B 100 mg/kg·d, i.g. | Normal saline | (1) VEGF | (1) ; 4 w | (1) Myocardial infarct size | (1) ; 4 w | No report |
| (2) BVD | (2) ; 4 w | (2) LVSP | (2) ; 4 w |
| (3) LVEDP | (3) ; 4 w |
| (4) LVEF | (4) ; 4 w |
|
| Li et al. [27] | Male Sprague Dawley rats (5/5) | 200–220 g | AMI | 24 hours after the surgery | 3.5% hydrochloride (3.5 mg/100 g, i.p.) | 10 mg/kg/d salvianolic acid A i.v. | Normal saline | (1) BVD | (1) ; 7 d | (1) Myocardial infarct size | (1) ; 1 w | No report |
| (2) VEGF | (2) ; 7 d |
|
| Yang [28] | Male Sprague Dawley rats (8/8) | 180–200 g | AMI | 1 week after the surgery | Urethane 1.2 g/kg, i.p. | Salvia extract (salvianolic acid B 20.6%; Danshensu 23.6%; protocatechualdehyde 3.9%) 100 mg/kg/d, i.g. | Normal saline | (1) VEGF | (1) ; 60 d | (1) LVSP | (1) ; 60 d | No report |
| (2) BVD | (2) ; 60 d | (2) LVEDP | (2) ; 60 d |
| (3) IL | (3) ; 60 d |
|
| Fang [29] | Male Sprague Dawley rats (13/13) | 220–260 g | AMI | 3 days after the surgery | 10% chloral hydrate (4 ml/kg, i.p.) | Salvianolate (main composition salvianolic acid B) 30 mg/kg·d, i.p. | Normal saline | (1) BVD | (1) ; 4 w | No | No | No report |
| (2) VEGF | (2) ; 4 w |
|
| Ma [30] | Male Sprague Dawley rats (10/10) | Three months Age | AMI | No report | 3% pentobarbital 45 mg/kg, i.p. | Salvianolic acid B 1 g/(kg·d), i.g. | Normal saline | (1) BVD | (1) ; 14 d | (1) Myocardial infarct size | (1) ; 14 d | No report |
|
| Li [31] | Male Sprague Dawley rats (5/5) | 200–220 g | AMI | 1 day after the surgery | 3.5% chloral hydrate (35 g/kg, i.p.) | Salvianolic acid A 10 mg/kg, i.v. | Normal saline | (1) BVD | (1) ; 1 w | (1) Myocardial infarct size | (1) ; 1 w | No report |
| (2) VEGF | (2) ; 1 w | (2) SDF-1 | (2) ; 1 w |
| (3) MMP-9 | (3) ; 1 w |
|
| Wang [32] | Male piglets (6/6) | 28 ± 10 kg | AMI | 1 day after the surgery | Ketamine, 20 mg/kg, and diazepam, 0.05 mg/kg, i.m. | Salvianolate (main composition salvianolic acid B) 400 mg, i.v. | Normal saline | (1) BVD | (1) ; 4 w | (1) LVEF | (1) ; 4 w | No report |
|
| Nuan-Liu [33] | Male Sprague Dawley rats (8/8) | 200–240 g | AMI | 2 days after the surgery | 10% chloral hydrate i.p. | Salvia extract (main composition salvianolic acid B) 40 mg/kg·d, i.g. | Normal saline | (1) VEGF | (1) ; 4 w | No | No | No report |
| (2) BVD | (2) ; 4 w |
|
| Chen [34] | Male/female Sprague Dawley rats (8/8) | 180–220 g | AMI | 1 day after the surgery | 3% pentobarbital 30 mg/kg i.p. | Salvianolic acid B 6.4 mg, i.v. | Normal saline | (1) VEGF | (1) ; 2 w | (1) Myocardial infarct size | (1) ; 2 w | No report |
| (2) BVD | (2) ; 2 w | (2) NO | (2) ; 2 w |
| (3) NOS | (3) ; 2 w |
|
| Fang [35] | Male/female Wistar rats (10/10) | 250 ± 50 g | AMI | 6 days before the surgery | 3% pentobarbital 30 mg/kg, i.p. | Salvianolic acid B 100 mg/(kg·d), i.g. | Normal saline | (1) BVD | (1) ; 6 d | (1) Myocardial infarct size | (1) ; 6 d | No report |
| (2) Fibroblast | (2) ; 6 d |
|
| Ye [36] | Male Sprague Dawley rats (6/7) | 240 ± 60 g | AMI | 48 h after the surgery | Ether inhaler | Salvia extract (main composition salvianolic acid B (40 mg/kg·d), i.g. | Normal saline1 | (1) VEGF | (1) ; 8 w | No | No | No report |
|
| Pang [37] | Male Sprague Dawley rats (10/11) | 180–220 g | AMI | 24 h after the surgery | Ether inhaler | Salvianolic acid B 120 mg/(kg·d) i.g | Normal saline | (1) BVD | (1) ; 2 w | (1) Myocardial infarct size | (1) ; 2 w | No report |
| (2) Ventricle thickness | (2) ; 2 w |
|
| Guo et al. [38] | Female SD rats (no report) | No report | AMI | No report | No report | 80 μl of phosphate-buffered saline (PBS) alone and 5 × 106 salvianolic acid B pretreated MSC/d | 80 μl of phosphate-buffered saline alone and 5 × 106 MSC/d | (1) BVD | (1) ; 4 w | No report | No report | No report |
| (2) VEGF | (2) ; 4 w |
|
