Roles and Mechanisms of Herbal Medicine for Diabetic Cardiomyopathy: Current Status and Perspective

Table 3

In vivo studies of herbs in the application of DCM.

Drug	Dosage	Administration	Experimental model	Reference
Triptolide	100, 200, or 400 μg/kg/d	p.o. 6 weeks	STZ-induced diabetic rat	[64, 65]
Triptolide	50, 100, or 200 μg/kg/d	p.o. 8 weeks	STZ-induced diabetic rat	[66]
Curcumin	100 mg/kg/d	p.o. 8 weeks	STZ-induced diabetic rat	[68]
C66	5 mg/kg/d	p.o. every other day for 12 weeks	STZ-induced diabetic mice	[69, 70]
EGb761	100 mg/kg/d	p.o. 12 weeks	STZ-induced diabetic rat	[71, 72]
EGb761	50 mg/kg/d	p.o. 3 weeks	STZ-induced diabetic rat	[75]
Resveratrol	2.5 mg/kg/d	p.o. 2 weeks	STZ-induced diabetic rat	[78]
Resveratrol	10 mg/kg/d	i.p. 4 weeks	STZ-induced diabetic rat	[80]
Resveratrol	Diet enriched with resveratrol at 0.067%	p.o. 12 weeks	STZ-induced diabetic mice	[52]
Astragalus polysaccharides	1-2 g/kg/d	p.o. 10 weeks	STZ-induced diabetic hamsters	[81–84]
Salvia miltiorrhiza	100 mg/kg/d	i.p. 4 weeks	STZ-induced diabetic rat	[86]
Cryptotanshinone	10 mg/kg/d	p.o. 28 days	STZ-induced diabetic rat	[87]
Myricitrin	300 mg/kg/d	p.o. 8 weeks	STZ-induced diabetic mice	[90]
Taxifolin	25, 50, 100 mg/kg/d	p.o. 4 weeks	STZ-induced diabetic mice	[92]
Troxerutin	150 mg/kg/d	p.o. 4 weeks	STZ-induced diabetic rat	[93]
Nobiletin	50 mg/kg/d	p.o. 11 weeks	STZ-induced diabetic mice	[95]
Liquirtin	8, 16 mg/kg	p.o. 10 weeks	High fructose-induced diabetic mice	[98]
Shengmaisan	4.5 g/kg/d	p.o. 24 weeks	db/db mice	[99]
Alcoholic ginseng root	200 mg/kg/d	p.o. 2 or 4 months	STZ-induced diabetic mice and db/db mice	[101]
Total saponins of Panax ginseng	30 mg/kg/d	p.o. 12 weeks	STZ-induced diabetic rat	[102]
Ginsenoside Rg1	10, 15, 20 mg/kg/d	i.p. 12 weeks	STZ-induced diabetic rat	[103]
Dendrobium officinale Kimura et Migo	75, 150, 300 mg/kg/d	p.o. 8 weeks	STZ-induced diabetic mice	[105]
Flos Puerariae extract	100, 200 mg/kg/d	p.o. 10 weeks	STZ-induced diabetic mice	[106]
Mangiferin	20 mg/kg/d	p.o. 16 weeks	STZ and high-fat diet induced diabetic rat	[107]
TASAES	4.9, 9.8, and 19.6 mg/kg/d	p.o. 8 weeks	STZ-induced diabetic rat	[108]
Berberine	100 mg/kg/d	p.o. 16 weeks	High-fat diet and STZ-induced diabetic rat	[111]

EGb761: Ginkgo biloba extract 761; TASAES: total aralosides of Aralia elata (Miq) seem.