Table 2: Effect of SM on estradiol benzoate and progestin induced mammary gland changes on histopathology.

GroupsMammary gland hyperplasiaLobule increaseAcinar increaseMammary duct and lumen ectasiaMammary duct and lumen secretion

FPEs control
EB + PR+++++++++++++++
EB + PR+ 30 ml FPEs/kg++++++/−
EB + PR+ 15 ml FPEs/kg++++++++++
EB + PR+ 5 ml FPEs/kg++++++++++++++

FPEs: fermented papaya extracts; EB: estradiol benzoate; PR: progestin. The histopathology changes were determined at the end of experiment. −: none; +/−: some have and some not; +: mild; ++: moderate; +++: severe.