Modulation of Glutathione Hemostasis by Inhibition of 12/15-Lipoxygenase Prevents ROS-Mediated Cell Death after Hepatic Ischemia and Reperfusion
Table 1
Serum analyses.
Sham
IRI
Control
DMSO
Baicalein
Control
DMSO
Baicalein
Creatinine (mg/dl)
0.8 ± 0
0.8 ± 0
0.8 ± 0
0.8 ± 0.0001
0.8 ± 0.0001
0.8 ± 0.0001
Bilirubin (mg/dl)
0.9 ± 0.1
1.1 ± 0.3
1.0 ± 0.2
1.1 ± 0.2
1.4 ± 0.3
1.3 ± 0.1
Cholinesterase (kU/l)
2.9 ± 0.1
3.2 ± 0.2
3.5 ± 0.2
2.9 ± 0.1
3.3 ± 0.1
3.3 ± 0.2
AST (U/l)
152.0 ± 34.3
315.8 ± 65.4
627.0 ± 102.0
697.2 ± 180.7
1162.8 ± 310.5
1780.5 ± 455.7
ALT (U/l)
121.0 ± 26.5
269.0 ± 73.781
243.0 ± 78.1
860.0 ± 291.7
1280.8 ± 427.0
1593.1 ± 626.9
GLDH (U/l)
14.5 ± 3.8
39.5 ± 18.3
89.8 ± 21.1
131.3 ± 25.7
230.3 ± 68.3
363.8 ± 132.9
Data presented as mean ± SEM. No significant differences between all groups could be stated regarding creatinine, bilirubin, and cholinesterase values. A relevant elevation of hepatic damage enzymes could be observed after Baicalein and sole DMSO application compared to the respective control in both Sham and IRI groups.
