Research Article
PPAR-γ Activation Prevents Septic Cardiac Dysfunction via Inhibition of Apoptosis and Necroptosis
Figure 1
Indices of cardiac systolic and diastolic function by a pressure-volume conductance catheter system in septic rats. PPAR-γ agonist rosiglitazone (ROT) or antagonist T007 was injected intravenously 1 hour before CLP. Cardiac function measured 18 hours after CLP was demonstrated in terms of (a) left ventricular systolic pressure (LVSP), (b) left ventricular end diastolic pressure (LVEDP), (c) maximal slope of left ventricular systolic pressure increment (LV dP/dtmax), and (d) maximal slope of left ventricular diastolic pressure decrement (LV −dP/dtmax). versus sham. # versus CLP. Data are presented as mean ± SEM. per group.
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