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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 8326749, 11 pages
https://doi.org/10.1155/2017/8326749
Research Article

PPAR-γ Activation Prevents Septic Cardiac Dysfunction via Inhibition of Apoptosis and Necroptosis

Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China

Correspondence should be addressed to Feng Xiao; moc.kooltuo@hcuotnisruoy

Received 1 June 2017; Accepted 10 July 2017; Published 3 August 2017

Academic Editor: Hong Zheng

Copyright © 2017 Shiyan Peng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Annane, E. Bellissant, and J. M. Cavaillon, “Septic shock,” Lancet, vol. 365, no. 9453, pp. 63–78, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. R. C. Bone, R. A. Balk, F. B. Cerra et al., “Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis,” Chest, vol. 101, no. 6, pp. 1644–1655, 1992. View at Publisher · View at Google Scholar
  3. D. B. Hoover, T. R. Ozment, R. Wondergem, C. Li, and D. L. Williams, “Impaired heart rate regulation and depression of cardiac chronotropic and dromotropic function in polymicrobial sepsis,” Shock, vol. 43, no. 2, pp. 185–191, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Thangamalai, K. Kandasamy, S. V. Sukumarn et al., “Atorvastatin prevents sepsis-induced downregulation of myocardial beta1-adrenoceptors and decreased cAMP response in mice,” Shock, vol. 41, no. 5, pp. 406–412, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. F. J. Romero-Bermejo, M. Ruiz-Bailen, J. Gil-Cebrian, and M. J. Huertos-Ranchal, “Sepsis-induced cardiomyopathy,” Current Cardiology Reviews, vol. 7, no. 3, pp. 163–183, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. J. W. Haveman, A. M. Kobold, J. C. Tervaert et al., “The central role of monocytes in the pathogenesis of sepsis: consequences for immunomonitoring and treatment,” The Netherlands Journal of Medicine, vol. 55, no. 3, pp. 132–141, 1999. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Oberholzer, C. Oberholzer, and L. L. Moldawer, “Sepsis syndromes: understanding the role of innate and acquired immunity,” Shock, vol. 16, no. 2, pp. 83–96, 2001. View at Publisher · View at Google Scholar
  8. A. Rudiger and M. Singer, “Mechanisms of sepsis-induced cardiac dysfunction,” Critical Care Medicine, vol. 35, no. 6, pp. 1599–1608, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Furian, C. Aguiar, K. Prado et al., “Ventricular dysfunction and dilation in severe sepsis and septic shock: relation to endothelial function and mortality,” Journal of Critical Care, vol. 27, no. 3, pp. 319.e9–145.e9, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. D. L. Carlson, M. S. Willis, D. J. White, J. W. Horton, and B. P. Giroir, “Tumor necrosis factor-alpha-induced caspase activation mediates endotoxin-related cardiac dysfunction,” Critical Care Medicine, vol. 33, no. 5, pp. 1021–1028, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. B. Zingarelli and J. A. Cook, “Peroxisome proliferator-activated receptor-gamma is a new therapeutic target in sepsis and inflammation,” Shock, vol. 23, no. 5, pp. 393–399, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Yki-Järvinen, “Thiazolidinediones,” The New England Journal of Medicine, vol. 351, no. 11, pp. 1106–1118, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. S. P. Senol, M. Temiz, D. S. Guden et al., “Contribution of PPARalpha/beta/gamma, AP-1, importin-alpha3, and RXRalpha to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock,” Inflammation Research, vol. 65, no. 5, pp. 367–387, 2016. View at Publisher · View at Google Scholar · View at Scopus
  14. W. T. Wu, C. C. Lee, C. J. Lee, Y. M. Subeq, R. P. Lee, and B. G. Hsu, “Rosiglitazone ameliorates endotoxin-induced organ damage in conscious rats,” Biological Research for Nursing, vol. 13, no. 1, pp. 38–43, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. C. V. Araújo, C. Campbell, C. F. Gonçalves-de-Albuquerque et al., “A PPARgamma agonist enhances bacterial clearance through neutrophil extracellular trap formation and improves survival in sepsis,” Shock, vol. 45, no. 4, pp. 393–403, 2016. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Kaplan, M. Nowell, R. Chima, and B. Zingarelli, “Pioglitazone reduces inflammation through inhibition of NF-kappaB in polymicrobial sepsis,” Innate Immunity, vol. 20, no. 5, pp. 519–528, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Drosatos, R. S. Khan, C. M. Trent et al., “Peroxisome proliferator-activated receptor-gamma activation prevents sepsis-related cardiac dysfunction and mortality in mice,” Circulation Heart Failure, vol. 6, no. 3, pp. 550–562, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Drosatos, Z. Drosatos-Tampakaki, R. Khan et al., “Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor alpha expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction,” The Journal of Biological Chemistry, vol. 286, no. 42, pp. 36331–36339, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. I. M. Kafa, M. Uysal, S. Bakirci, and K. M. Ayberk, “Sepsis induces apoptotic cell death in different regions of the brain in a rat model of sepsis,” Acta Neurobiologiae Experimentalis, vol. 70, no. 3, pp. 246–260, 2010. View at Google Scholar
  20. A. Iwata, R. A. Claro, V. L. Morgan-Stevenson et al., “Extracellular administration of BCL2 protein reduces apoptosis and improves survival in a murine model of sepsis,” PLoS One, vol. 6, no. 2, article e14729, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Newton, D. L. Dugger, A. Maltzman et al., “RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury,” Cell Death and Differentiation, vol. 23, no. 9, pp. 1565–1576, 2016. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Nogusa, R. J. Thapa, C. P. Dillon et al., “RIPK3 activates parallel pathways of MLKL-driven necroptosis and FADD-mediated apoptosis to protect against influenza a virus,” Cell Host & Microbe, vol. 20, no. 1, pp. 13–24, 2016. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Kalbitz, F. Fattahi, J. J. Grailer et al., “Complement-induced activation of the cardiac NLRP3 inflammasome in sepsis,” The FASEB Journal, vol. 30, no. 12, pp. 3997–4006, 2016. View at Publisher · View at Google Scholar · View at Scopus
  24. B. Zhang, Y. Liu, J. S. Zhang et al., “Cortistatin protects myocardium from endoplasmic reticulum stress induced apoptosis during sepsis,” Molecular and Cellular Endocrinology, vol. 406, pp. 40–48, 2015. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Li, W. Yao, M. G. Irwin et al., “Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activating Nrf2 and Brg1,” Free Radical Biology and Medicine, vol. 84, pp. 311–321, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Li, W. Yao, Z. Liu et al., “Hyperglycemia abrogates ischemic postconditioning cardioprotection by impairing AdipoR1/Caveolin-3/STAT3 signaling in diabetic rats,” Diabetes, vol. 65, no. 4, pp. 942–955, 2016. View at Publisher · View at Google Scholar · View at Scopus
  27. J. D. Hunter and M. Doddi, “Sepsis and the heart,” British Journal of Anaesthesia, vol. 104, no. 1, pp. 3–11, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. R. S. Hotchkiss and D. W. Nicholson, “Apoptosis and caspases regulate death and inflammation in sepsis,” Nature Reviews Immunology, vol. 6, no. 11, pp. 813–822, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Zhang, S. S. Su, S. Zhao et al., “RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome,” Nature Communications, vol. 8, article 14329, 2017. View at Publisher · View at Google Scholar
  30. B. A. Potz, F. W. Sellke, and M. R. Abid, “Endothelial ROS and impaired myocardial oxygen consumption in sepsis-induced cardiac dysfunction,” Journal of Intensive and Critical Care, vol. 2, no. 1, 2016. View at Publisher · View at Google Scholar
  31. G. Lee, F. Elwood, J. McNally et al., “T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities,” The Journal of Biological Chemistry, vol. 277, no. 22, pp. 19649–19657, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. D. G. Remick, G. R. Bolgos, J. Siddiqui, J. Shin, and J. A. Nemzek, “Six at six: interleukin-6 measured 6 h after the initiation of sepsis predicts mortality over 3 days,” Shock, vol. 17, no. 6, pp. 463–467, 2002. View at Publisher · View at Google Scholar
  33. J. A. Buras, B. Holzmann, and M. Sitkovsky, “Animal models of sepsis: setting the stage,” Nature Reviews Drug Discovery, vol. 4, no. 10, pp. 854–865, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. A. E. Ferreira, F. Sisti, F. Sônego et al., “PPAR-gamma/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis,” Journal of Immunology, vol. 192, no. 5, pp. 2357–2365, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. S. W. Standage, C. C. Caldwell, B. Zingarelli, and H. R. Wong, “Reduced peroxisome proliferator-activated receptor alpha expression is associated with decreased survival and increased tissue bacterial load in sepsis,” Shock, vol. 37, no. 2, pp. 164–169, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Aziz, A. Jacob, and P. Wang, “Revisiting caspases in sepsis,” Cell Death & Disease, vol. 5, article e1526, 2014. View at Publisher · View at Google Scholar · View at Scopus
  37. F. Humphries, S. Yang, B. Wang, and P. N. Moynagh, “RIP kinases: key decision makers in cell death and innate immunity,” Cell Death and Differentiation, vol. 22, no. 2, pp. 225–236, 2015. View at Publisher · View at Google Scholar · View at Scopus
  38. J. C. Alves-Filho, F. Spiller, and F. Q. Cunha, “Neutrophil paralysis in sepsis,” Shock, vol. 34, Supplement 1, pp. 15–21, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Conrad, J. P. Angeli, P. Vandenabeele, and B. R. Stockwell, “Regulated necrosis: disease relevance and therapeutic opportunities,” Nature Reviews Drug Discovery, vol. 15, no. 5, pp. 348–366, 2016. View at Publisher · View at Google Scholar · View at Scopus