A Single Zidovudine (AZT) Administration Delays Hepatic Cell Proliferation by Altering Oxidative State in the Regenerating Rat Liver
Effects of AZT administration on some parameters indicative of cell proliferation and apoptosis at various times after 70%-PH. Results are expressed as mean ± SE for four independent determinations per experimental point for panel (a). The activity of TK expressed as nmoles of formed -TMP⋅h−1⋅mg−1 of cytosolic protein, in panel (b). The number of mitotic cells per microscopic field, as well as the cytosolic activity of caspase-3 (apoptosis) expressed as Relative Fluorescence Units (RFU)⋅min−1⋅mg−1 of protein (panel (c)). Symbols for the experimental groups at the bottom of each figure. Statistical significance: against Sham-operated (control) rats, and versus the PH group.