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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 8370593, 14 pages
https://doi.org/10.1155/2017/8370593
Research Article

Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO-1

Hai-han Liao,1,2,3 Jin-xiu Zhu,1,2,3 Hong Feng,4 Jian Ni,1,2,3 Nan Zhang,1,2,3 Si Chen,2,3 Huang-jun Liu,1,2,3 Zheng Yang,1,2,3 Wei Deng,1,2,3 and Qi-Zhu Tang1,2,3

1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
2Cardiovascular Research Institute of Wuhan University, Wuhan, China
3Hubei Key Laboratory of Cardiology, Wuhan, China
4Department of Gerontology, Renmin Hospital of Wuhan University, Wuhan 430060, China

Correspondence should be addressed to Qi-Zhu Tang; nc.ude.uhw@gnatzq

Received 12 May 2017; Revised 18 July 2017; Accepted 26 July 2017; Published 24 September 2017

Academic Editor: Silvana Hrelia

Copyright © 2017 Hai-han Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Tate, D. J. Grieve, and R. H. Ritchie, “Are targeted therapies for diabetic cardiomyopathy on the horizon?” Clinical Science, vol. 131, pp. 897–915, 2017. View at Publisher · View at Google Scholar
  2. P. M. Seferovic and W. J. Paulus, “Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes,” European Heart Journal, vol. 36, pp. 1718–1727, 2015, 1727a-1727c. View at Publisher · View at Google Scholar · View at Scopus
  3. M. X. Zhao, B. Zhou, L. Ling et al., “Salusin-beta contributes to oxidative stress and inflammation in diabetic cardiomyopathy,” Cell Death & Disease, vol. 8, article e2690, 2017. View at Publisher · View at Google Scholar
  4. A. Faria and S. J. Persaud, “Cardiac oxidative stress in diabetes: mechanisms and therapeutic potential,” Pharmacology & Therapeutics, vol. 172, pp. 50–62, 2017. View at Publisher · View at Google Scholar · View at Scopus
  5. M. M. Sung, S. M. Hamza, and J. R. Dyck, “Myocardial metabolism in diabetic cardiomyopathy: potential therapeutic targets,” Antioxidants & Redox Signaling, vol. 22, pp. 1606–1630, 2015. View at Publisher · View at Google Scholar · View at Scopus
  6. R. A. Kowluru and M. Mishra, “Oxidative stress, mitochondrial damage and diabetic retinopathy,” Biochimca et Biophysica Acta, vol. 1852, pp. 2474–2483, 2015. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Ramprasath and G. S. Selvam, “Potential impact of genetic variants in Nrf2 regulated antioxidant genes and risk prediction of diabetes and associated cardiac complications,” Current Medicinal Chemistry, vol. 20, pp. 4680–4693, 2013. View at Google Scholar
  8. A. D. Pradhan, J. E. Manson, N. Rifai, J. E. Buring, and P. M. Ridker, “C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus,” JAMA, vol. 286, pp. 327–334, 2001. View at Google Scholar
  9. G. Du, L. Sun, R. Zhao et al., “Polyphenols: potential source of drugs for the treatment of ischaemic heart disease,” Pharmacology & Therapeutics, vol. 162, pp. 23–34, 2016. View at Publisher · View at Google Scholar · View at Scopus
  10. D. K. Semwal, R. B. Semwal, S. Combrinck, and A. Viljoen, “Myricetin: a dietary molecule with diverse biological activities,” Nutrients, vol. 8, p. 90, 2016. View at Publisher · View at Google Scholar · View at Scopus
  11. M. G. Hertog, E. J. Feskens, P. C. Hollman, M. B. Katan, and D. Kromhout, “Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen elderly study,” Lancet, vol. 342, pp. 1007–1011, 1993. View at Google Scholar
  12. J. M. Geleijnse, L. J. Launer, D. A. Van der Kuip, A. Hofman, and J. C. Witteman, “Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam study,” American Journal of Clinical Nutrition, vol. 75, pp. 880–886, 2002. View at Google Scholar
  13. S. Qin, J. Chen, S. Tanigawa, and D. X. Hou, “Microarray and pathway analysis highlight Nrf2/ARE-mediated expression profiling by polyphenolic myricetin,” Molecular Nutrition & Food Research, vol. 57, pp. 435–446, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. H. H. Liao, N. Zhang, H. Feng et al., “Oleanolic acid alleviated pressure overload-induced cardiac remodeling,” Molecular and Cellular Biochemistry, vol. 409, pp. 145–154, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Yuan, L. Yan, Q. Q. Wu et al., “Mnk1 (mitogen-activated protein kinase-interacting kinase 1) deficiency aggravates cardiac remodeling in mice,” Hypertension, vol. 68, pp. 1393–1399, 2016. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Kayama, U. Raaz, A. Jagger et al., “Diabetic Cardiovascular Disease Induced by Oxidative Stress,” International Journal of Molecular Sciences, vol. 16, no. 10, pp. 25234–25263, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Tan, T. Ichikawa, J. Li et al., “Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo,” Diabetes, vol. 60, pp. 625–633, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Bai, W. Cui, Y. Xin et al., “Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation,” Journal of Molecular and Cellular Cardiology, vol. 57, pp. 82–95, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. H. K. Bayele, E. S. Debnam, and K. S. Srai, “Nrf2 transcriptional derepression from Keap1 by dietary polyphenols,” Biochemical and Biophysical Research Communications, vol. 469, pp. 521–528, 2016. View at Publisher · View at Google Scholar · View at Scopus
  20. S. F. Nabavi, A. J. Barber, C. Spagnuolo et al., “Nrf2 as molecular target for polyphenols: a novel therapeutic strategy in diabetic retinopathy,” Critical Reviews in Clinical Laboratory Sciences, vol. 53, pp. 293–312, 2016. View at Publisher · View at Google Scholar · View at Scopus
  21. R. K. Thimmulappa, H. Lee, T. Rangasamy et al., “Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis,” Journal of Clinical Investigation, vol. 116, pp. 984–995, 2006. View at Google Scholar
  22. B. O. Cho, H. H. Yin, S. H. Park, E. B. Byun, H. Y. Ha, and S. I. Jang, “Anti-inflammatory activity of myricetin from Diospyros lotus through suppression of NF-κB and STAT1 activation and Nrf2-mediated HO-1 induction in lipopolysaccharide-stimulated RAW264.7 macrophages,” Bioscience Biotechnology and Biochemistry, vol. 80, pp. 1520–1530, 2016. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Wang, L. Hu, X. L. Jin et al., “Polyphenol-rich propolis extracts from China and Brazil exert anti-inflammatory effects by modulating ubiquitination of TRAF6 during the activation of NF-κB,” Journal of Functional Foods, vol. 19, Part A, pp. 464–478, 2015. View at Google Scholar
  24. C. H. Little, E. Combet, D. C. McMillan, P. G. Horgan, and C. S. Roxburgh, “The role of dietary polyphenols in the moderation of the inflammatory response in early stage colorectal cancer,” Critical Reviews in Food Science and Nutrition, vol. 57, pp. 2310–2320, 2017. View at Publisher · View at Google Scholar
  25. I. Russo and N. G. Frangogiannis, “Diabetes-associated cardiac fibrosis: cellular effectors, molecular mechanisms and therapeutic opportunities,” Journal of Molecular and Cellular Cardiology, vol. 90, pp. 84–93, 2016. View at Publisher · View at Google Scholar · View at Scopus
  26. L. van Heerebeek, N. Hamdani, M. L. Handoko et al., “Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension,” Circulation, vol. 117, pp. 43–51, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. I. Falcao-Pires, N. Hamdani, A. Borbely et al., “Diabetes mellitus worsens diastolic left ventricular dysfunction in aortic stenosis through altered myocardial structure and cardiomyocyte stiffness,” Circulation, vol. 124, pp. 1151–1159, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Suzuki, Y. Kayama, M. Sakamoto et al., “Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy,” Diabetes, vol. 64, pp. 618–630, 2015. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Fiaschi, F. Magherini, T. Gamberi et al., “Hyperglycemia and angiotensin II cooperate to enhance collagen I deposition by cardiac fibroblasts through a ROS-STAT3-dependent mechanism,” Biochimica et Biophysica Acta, vol. 1843, pp. 2603–2610, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. V. P. Singh, B. Le, R. Khode, K. M. Baker, and R. Kumar, “Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis,” Diabetes, vol. 57, pp. 3297–3306, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Biernacka, M. Cavalera, J. Wang et al., “Smad3 signaling promotes fibrosis while preserving cardiac and aortic geometry in obese diabetic mice,” Circulation-Heart Failure, vol. 8, pp. 788–798, 2015. View at Publisher · View at Google Scholar · View at Scopus