Cytotoxicity Study of Cyclopentapeptide Analogues of Marine Natural Product Galaxamide towards Human Breast Cancer Cells

Table 1

Cytotoxicity of galaxamide and its analogues towards various cancer cell lines and normal cells as determined by MTT assay. Data expressed as mean ± SD from three independent experiments.

Compound	IC50 (μg/mL) values in various cell lines
	HepG2	MCF-7	HeLa	MD-MBA-231	HUVECs
Galaxamide	4.23 ± 0.18	10.25 ± 1.89	9.75 ± 1.36	8.27 ± 0.94	>40
1	6.25 ± 1.03	4.76 ± 1.36	13.22 ± 1.12	5.83 ± 0.45	>40
2	8.42 ± 1.82	3.16 ± 0.92	6.43 ± 1.20	4.48 ± 2.24	>40
3	3.98 ± 0.71	1.72 ± 0.85	5.32 ± 0.42	3.51 ± 1.32	>40
DPP	10.43 ± 1.23	14.61 ± 2.01	8.90 ± 0.89	13.75 ± 0.56
Doxorubicin	2.27 ± 0.24	0.50 ± 0.48	0.32 ± 0.22	1.29 ± 0.57