Review Article

Astragaloside IV for Experimental Focal Cerebral Ischemia: Preclinical Evidence and Possible Mechanisms

Table 1

The main compounds isolated from Radix Astragali seu Hedysari (Huangqi).

Category Main compounds

SaponinCaspicuside I, Astragalus saponin I–IV, Acetyl Astragalus saponin I, Isoastragaloside IV, Sphondin, Astragaloside I–IV, Astragalus saponins I, Astragalus saponins IV, Astragalus saponins VII, Astragalus aglycone, Baibutoside, Cyclogalegigenin, Saponin-Huangqiyiesaponin C, Mongholicoside A, Mongholicoside B, Tetracyclic triterpenoids, Cotton wool Astragalus saponins, 3-O-β-D-Xylopyraosyl-24S-cycloart-3β,6α,16β,24,25-pentaol-25-O-β-D-glucopyranoside, Isoastragaloside IV, Cyclocanthoside A, Cyclounifoliside C, Asernestioside C, 6,3′-Dihydroxy-2′,4′-dimethoxyisoflavan-6-O-β-Dglucopyranoside, Calycosin-7-O-β-D-glucoside, 7,3′-Dihydroxyl-6,4′-dimethoxyisoflavon-7-O-β-D-glucopyranoside, β-Sitosterol, β-Daucosterol
Polysaccharideα-(1→4) (1→6) glucan, α-(1→4) glucan
(including glucan and heteropolysaccharide)That is, glucose, galactose, arabinose, rhamnose, mannose, xylose, fucose, fructose, ribose, glucuronic acid, galacturonic acid
FlavonoidKaempferol, Quercetin, Isorhamnetin, Narcissin, Nicotiflorin, Microcephalin I, Microcephalin II, Rhamnocitin, (3R)-2′,3′-Dihydroxy-7,4-dimethyl oxygen radicals isoflavone, Rutin, (6aR,11aR)-10-Hydroxy-3,9-Dimethyl oxygen radicals red sandalwood alkyl, 1′-Hydroxy-7,3′,4,-trimethoxy isoflavone, Odoratin-7-O-β-D-glucoside, Salvigenin, Apigenin, Luteolin, 7,3′-Dihydroxy-6,4′-dimethoxyisoflavone, 7-Hydroxyflavone, Formononetin-7-O-β-D-glycoside-6′′-O-acetate, (6aR,11aR)-3-Hydroxy-9,10-dimethoxy-pterocarpan, Calycosin-7-O-β-D-glucoside-6′′-O-malonate, Formononetin-7-O-β-D-glucoside-6′′-D-malonate, (6aR,11aR)-3-Hydroxy-9,10-dimethoxypterocarpan, (3R)-7,2′-Dihydroxy-3′,4′-dimethoxyisoflavan, Astrapterocarpanglucoside-6′-O-malonate, Astraisoflavanglucoside-6′-O-malonate, Calycosin-7-O-β-D-glucoside-6′′-O-acetate
Amino acidAsparagine, canavanine, proline, arginine, aspartic acid, alanine
trace elementscandium, chromium, cobalt, copper, selenium, molybdenum, cesium, iron, manganese, zinc, rubidium
Other compoundsCoumarin, folic acid, bitter elements, choline, betaine, linoleic acid, linolenic acid, vanillic acid, ferulic acid, isoferulic acid, paimitie acid, hydroxy phenyl acrylic acid, caffeic acid, green acid, palm acid, 13-sitosterol, daucosterol, lupeol