Effect of Chronic Administration of Resveratrol on Cognitive Performance during Aging Process in Rats

Figure 4

Effect of resveratrol on the hippocampus cytoarchitecture in the CA2 region in rats of 2, 4, 6, and 8 months of treatment (20×). (a) Control group of 2 months. (b) Control group of 4 months. (c) Control group of 6 months. (d) Control group of 8 months. The CA2 region of the hippocampus is observed, and it is interesting to note the arrangement of the cells and the axonal projections; this region does not result in severe alterations as observed, but the gradual changes lead to the disorganization that as observed in the CA1 region is present in different brain regions. (e) Vehicle group of 2 months. (f) Vehicle group of 4 months. (g) Vehicle group of 6 months. (h) Vehicle group of 8 months. Cellular cytoarchitecture is compromised over time, and changes due to cellular disorganization are more noticeable. (i) Group administered with vitamin E for 2 months. (j) Vitamin E group of 4 months. (k) Vitamin E group of 6 months. (l) Vitamin E group of 8 months. The organization of cells is conserved and changes with respect to time are minimal. (m) Group administered with resveratrol for 2 months. (n) Group administered with resveratrol for 4 months. (o) Resveratrol group of 6 months. (p) Resveratrol group of 8 months. The CA2 region of the hippocampus retains its integrity until after 6 months of treatment and then presents characteristic changes of aging. The arrows indicate areas where there are scattered cells or changes in the organization of cells.