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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 8523728, 10 pages
Review Article

Physical Exercise on Inflammatory Markers in Type 2 Diabetes Patients: A Systematic Review of Randomized Controlled Trials

1Programa de Pós-Graduação em Ciências da Saúde, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Campus A. C. Simões, Av. Lourival Melo Mota, s/n, Tabuleiro do Martins, 57072-900 Maceió, AL, Brazil
2Laboratório de Reatividade Cardiovascular, Setor de Fisiologia, Núcleo de Síndrome Metabólica, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, AL, Brazil
3Instituto Nacional de Ciência e Tecnologia em Nanobiofarmacêutica (N-BIOFAR), Belo Horizonte, MG, Brazil
4Max Delbrück Center for Molecular Medicine, Berlin, Germany

Correspondence should be addressed to Fabiano Timbó Barbosa; rb.moc.oohay@obmitonaibaf and Luiza A. Rabelo; moc.liamg@olebar.aaziul

Received 15 October 2016; Revised 7 December 2016; Accepted 23 February 2017; Published 19 March 2017

Academic Editor: Sara Baldelli

Copyright © 2017 Luciana Costa Melo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Type 2 diabetes mellitus (T2DM) is a serious disease associated with high morbidity and mortality. Scientific findings showed that physical exercise is an option for treatment of these patients. This study’s objective is to investigate the effects of supervised aerobic and/or resistance physical training on inflammatory markers in subjects with T2DM. Methods. A systematic review was conducted on four databases, MEDLINE, CENTRAL, LILACS, and Scopus, and manual search from 21 to 30 November 2016. Randomized clinical trials involving individuals diagnosed with T2DM, who have undergone supervised training protocols, were selected in this study. Results. Eleven studies were included. Studies that evaluated control group versus aerobic exercise reported controversial results about the effectiveness of physical training in modifying C-reactive protein (CRP) and cytokine levels. The only variable analyzed by the six studies in comparison to the control group versus resistance exercise was CRP. This protein showed no significant difference between groups. Between the two modes of exercise (aerobic and resistance), only one study demonstrated that aerobic exercise was more effective in reducing CRP. Conclusion. The evidence was insufficient to prove that aerobic or resistance exercise improves systemic levels of inflammatory markers in patients with T2DM.