Paradoxical Effect of Nonalcoholic Red Wine Polyphenol Extract, Provinols™, in the Regulation of Cyclooxygenases in Vessels from Zucker Fatty Rats (fa/fa)

Figure 2

Effect of NO inhibition on vasoreactivity in aortas and SMA from obese ZF rats. Shown are concentration-response curves to phenylephrine (Phe) cumulative concentrations (M) in the presence of NO-synthase nonselective inhibitor (L-NAME) of small mesenteric arteries (SMA) (a–c) and rat aortic rings (d–f) from ZF rats treated or not with Provinols. Values are expressed as mean ± SEM of millinewtons (mN) per mm of vessel length. versus ZF rats.

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