Paradoxical Effect of Nonalcoholic Red Wine Polyphenol Extract, Provinols™, in the Regulation of Cyclooxygenases in Vessels from Zucker Fatty Rats (fa/fa)

Figure 4

Provinols reduced the involvement of COX-derived vasoconstrictor metabolites in the aorta from obese ZF rats. Concentration-response curves to phenylephrine (Phe) cumulative concentrations (M) in the presence of COX-2 inhibitor (NS398) or the nonselective COX inhibitor (indomethacin, INDO) of aorta rings from ZF rats which received or not Provinols. Values are expressed as mean ± SEM of millinewtons (mN) per mm of vessel length. in each group. versus ZF rats.

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