Therapeutic Hypothermia Reduces Oxidative Damage and Alters Antioxidant Defenses after Cardiac Arrest
Table 2
Biomarkers of outcome in patients with postcardiac arrest syndrome (PCAS).
Normothermic patients
Hypothermic patients
6 h
12 h
36 h
72 h
6 h
12 h
36 h
72 h
Temperature, °C
35.6 ± 0.27
35.7 ± 0.21
35.6 ± 0.53
36.1 ± 0.15
32.9 ± 0.25+,#
32.6 ± 0.31+,#
36.1 ± 0.30
36.1 ± 0.20
Hs-CRP, mg/L
114.6 ± 20.92
n.a.
178.4 ± 36.1
141.2 ± 44.3
173.4 ± 31.7
n.a.
161.8 ± 38.82
205.9 ± 65.18
S100B, ng/mL
0.13 (0.01;6.63)+
0.07 (0.01;1.42)
0.06 (0.001;1.8)
0.50 (0.01;1.3)
0.15 (0.02;1.8)+
0.09 (0.04;0.71)
0.04 (0.01;0.6)
0.03 (0.02;1.10)
Venous pH
7.28 ± 0.04
7.36 ± 0.04
7.33 ± 0.06
7.35 ± 0.03
7.20 ± 0.05
7.28 ± 0.05
7.34 ± 0.043
7.32 ± 0.07
Glucose, mg/dL
123.6 ± 16.03+
126.6 ± 8.47+
138.9 ± 9.35
167.3 ± 24.11
179.2 ± 22.43+,#
155.3 ± 22.43#
129.0 ± 8.42
107.3 ± 11.22
Lactate, mmol/L
2.9 (0.8;13.7)+
1.8 (0.7;17)
1.4 (0.7;11.8)
1.7 (0.5;8.5)
1.9 (0.6;18)+
1.8 (0.6;19)
1.6 (1.0;4.2)
1.4 (0.6;1.5)
Sodium, mmol/L
136.4 ± 1.54
136.9 ± 1.48
136.2 ± 1.70
134.0 ± 2.11
135.5 ± 2.46
104.1 ± 1.98
134.6 ± 3.36
140.3 ± 1.70
Calcium, mg/dL
1.04 ± 0.025
1.09 ± 0.07
1.05 ± 0.04
1.06 ± 0.06
1.05 ± 0.02
1.04 ± 0.02
1.03 ± 0.03
1.13 ± 0.03
Hs-PCR: high-sensitivity C-reactive protein; data are expressed as mean ± standard error, except for S100B and lactate, which are expressed as median (min; max); + is significantly different among time points within the normothermic or hypothermic group, ; # is significantly different when comparing normothermic versus hypothermic groups at the same time point, .
