Oxidative Medicine and Cellular Longevity / 2017 / Article / Tab 2

Research Article

Therapeutic Hypothermia Reduces Oxidative Damage and Alters Antioxidant Defenses after Cardiac Arrest

Table 2

Biomarkers of outcome in patients with postcardiac arrest syndrome (PCAS).

Normothermic patientsHypothermic patients
6 h12 h36 h72 h6 h12 h36 h72 h

Temperature, °C35.6 ± 0.2735.7 ± 0.2135.6 ± 0.5336.1 ± 0.1532.9 ± 0.25+,#32.6 ± 0.31+,#36.1 ± 0.3036.1 ± 0.20
Hs-CRP, mg/L114.6 ± 20.92n.a.178.4 ± 36.1141.2 ± 44.3173.4 ± 31.7n.a.161.8 ± 38.82205.9 ± 65.18
S100B, ng/mL0.13
(0.01;6.63)+
0.07
(0.01;1.42)
0.06
(0.001;1.8)
0.50
(0.01;1.3)
0.15
(0.02;1.8)+
0.09
(0.04;0.71)
0.04
(0.01;0.6)
0.03
(0.02;1.10)
Venous pH7.28 ± 0.047.36 ± 0.047.33 ± 0.067.35 ± 0.037.20 ± 0.057.28 ± 0.057.34 ± 0.0437.32 ± 0.07
Glucose, mg/dL123.6 ± 16.03+126.6 ± 8.47+138.9 ± 9.35167.3 ± 24.11179.2 ± 22.43+,#155.3 ± 22.43#129.0 ± 8.42107.3 ± 11.22
Lactate, mmol/L2.9 (0.8;13.7)+1.8 (0.7;17)1.4 (0.7;11.8)1.7 (0.5;8.5)1.9 (0.6;18)+1.8 (0.6;19)1.6 (1.0;4.2)1.4 (0.6;1.5)
Sodium, mmol/L136.4 ± 1.54136.9 ± 1.48136.2 ± 1.70134.0 ± 2.11135.5 ± 2.46104.1 ± 1.98134.6 ± 3.36140.3 ± 1.70
Calcium, mg/dL1.04 ± 0.0251.09 ± 0.071.05 ± 0.041.06 ± 0.061.05 ± 0.021.04 ± 0.021.03 ± 0.031.13 ± 0.03

Hs-PCR: high-sensitivity C-reactive protein; data are expressed as mean ± standard error, except for S100B and lactate, which are expressed as median (min; max); + is significantly different among time points within the normothermic or hypothermic group, ; # is significantly different when comparing normothermic versus hypothermic groups at the same time point, .

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