Risperidone-Induced Renal Damage and Metabolic Side Effects: The Protective Effect of Resveratrol

Figure 3

Effects of risperidone, resveratrol, and their coadministration on the level of TAS, TOS, and OSI in rats after two weeks. Values are expressed as mean ± SEM of seven animals. ANOVA followed by the LSD post hoc test were used. versus control; ^# versus RIS-treated rats; ^† versus RIS+RSV-1-treated rats; ^& versus RIS+RSV-2-treated rats; and ^£ versus RIS+RSV-3-treated rats. Abbreviations: RIS, risperidone; RSV, resveratrol; TAS, total antioxidant status; TOS, total oxidant status; OSI, oxidative stress index; RIS+RSV-1, 2 mg/kg RIS+20 mg/kg RSV; RIS+RSV-2, 2 mg/kg RIS+40 mg/kg RSV; RIS+RSV-3, 2 mg/kg RIS+80 mg/kg RSV; AU: arbitrary units.