Risperidone-Induced Renal Damage and Metabolic Side Effects: The Protective Effect of Resveratrol

Table 1

Body weight (g) of animals during treatment.

Design of treatment	Control	RIS	RIS+RSV-1	RIS+RSV-2	RIS+RSV-3
Initial study	238.28 ± 7.53	234.57 ± 7.27	225.28 ± 4.16	232.40 ± 3.55	244.80 ± 9.88
Final study	252.85 ± 7.46	248.00 ± 5.86	233.71 ± 3.68	226.80 ± 5.25	246.80 ± 9.42
Statistical comparison (initial study versus final study)			()
Control			0.000
RIS			0.005
RIS+RSV-1			0.005
RIS+RSV-2			0.071
RIS+RSV-3			0.537

Changes in the body weight of experimental rats. Values are expressed as mean ± SEM of seven animals. The groups were compared with the paired-samples t-test at initial and final treatment. . RIS: risperidone; RSV: resveratrol; RIS+RSV-1: 2 mg/kg RIS+20 mg/kg RSV; RIS+RSV-2: 2 mg/kg RIS+40 mg/kg RSV; RIS+RSV-3: 2 mg/kg RIS+80 mg/kg RSV.