Risperidone-Induced Renal Damage and Metabolic Side Effects: The Protective Effect of Resveratrol

Table 2

Levels of serum biochemical parameters for all groups.

Parameters	Control	RIS	RIS+RSV-1	RIS+RSV-2	RIS+RSV-3
Scr (mg/dL)	0.46 ± 0.00^b,d,e	0.53 ± 0.00^a,c,d,e	0.45 ± 0.01^b,d,e	0.38 ± 0.01^a,b,c	0.37 ± 0.01^a,b,c	0.000
BUN (mg/dL)	18.71 ± 0.68^b,d,e	25.85 ± 0.45^a,c,d	19.85 ± 0.50^b,d,e	23.28 ± 0.42^a,b,c	24.57 ± 0.48^a,c	0.000

Each group represents the mean ± SEM for seven rats. ^a versus the control group; ^b versus the RIS group; ^c versus the RIS+RSV-1 group; ^d versus the RIS+RSV-2 group; and ^e versus the RIS+RSV-3 group. RIS: risperidone; RSV: resveratrol; Scr: serum creatinine; BUN: blood urea nitrogen; RIS+RSV-1: 2 mg/kg RIS+20 mg/kg RSV; RIS+RSV-2: 2 mg/kg RIS+40 mg/kg RSV; RIS+RSV-3: 2 mg/kg RIS+80 mg/kg RSV.