Research Article
Risperidone-Induced Renal Damage and Metabolic Side Effects: The Protective Effect of Resveratrol
Table 4
Effects of risperidone and resveratrol on apoptotic index (%) in rat kidneys.
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The apoptotic index of all the groups. Values are mean ± SD for seven rats in each group. aSignificant from control; bSignificant from RIS; cSignificant from RIS+RSV-1; dSignificant from RIS+RSV-2; and eSignificant from RIS+RSV-3 (). RIS: risperidone; RSV: resveratrol; RIS+RSV-1: 2 mg/kg RIS+20 mg/kg RSV; RIS+RSV-2: 2 mg/kg RIS+40 mg/kg RSV; RIS+RSV-3: 2 mg/kg RIS+80 mg/kg RSV. The extent of TUNEL staining was scored semiquantitatively as 0 (none), 1 (light), 2 (medium), and 3 (intense). |