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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 8785042, 8 pages
https://doi.org/10.1155/2017/8785042
Research Article

Effects of Redox Modulation on Cell Proliferation, Viability, and Migration in Cultured Rat and Human Tendon Progenitor Cells

1Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
2Department of Orthopaedics and Traumatology, Prince of Wales Hospital, Shatin, Hong Kong

Correspondence should be addressed to Leung Kim Hung; kh.ude.khuc@gnuhmikgnuel

Received 12 January 2017; Revised 26 April 2017; Accepted 18 May 2017; Published 2 July 2017

Academic Editor: Consuelo Borrás

Copyright © 2017 Yuk Wa Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. L. Butler, N. Juncosa, and M. R. Dressler, “Functional efficacy of tendon repair processes,” Annual Review of Biomedical Engineering, vol. 6, pp. 303–329, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Yang, B. B. Rothrauff, and R. S. Tuan, “Tendon and ligament regeneration and repair: clinical relevance and developmental paradigm,” Birth Defects Research Part C, Embryo Today, vol. 99, no. 3, pp. 203–222, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. Bi, D. Ehirchiou, T. M. Kilts et al., “Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche,” Nature Medicine, vol. 13, no. 10, pp. 1219–1227, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. Y.-F. Rui, P. P. Y. Lui, G. Li, S. C. Fu, Y. W. Lee, and K. M. Chan, “Isolation and characterization of multipotent rat tendon derived stem cells,” Tissue Engineering Part A, vol. 16, no. 5, pp. 1549–1558, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Ni, P. P. Lui, Y. F. Rui et al., “Tendon-derived stem cells (TDSCs) promote tendon repair in a rat patellar tendon window defect model,” Journal of Orthopaedic Research, vol. 30, no. 4, pp. 613–619, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. D. Docheva, S. A. Muller, M. Majewski, and C. H. Evans, “Biologics for tendon repair,” Advanced Drug Delivery Reviews, vol. 84, pp. 222–239, 2015. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Badr, W. N. Hozzein, B. M. Badr, A. Al Ghamdi, H. M. Saad Eldien, and O. Garraud, “Bee venom accelerates wound healing in diabetic mice by suppressing activating transcription factor-3 (ATF-3) and inducible nitric oxide synthase (iNOS)-mediated oxidative stress and recruiting bone marrow-derived endothelial progenitor cells,” Journal of Cellular Physiology, vol. 231, no. 10, pp. 2159–2171, 2016. View at Publisher · View at Google Scholar · View at Scopus
  8. L. K. Hung, S. C. Fu, Y. W. Lee, T. Y. Mok, and K. M. Chan, “Local vitamin-C injection reduced tendon adhesion in a chicken model of flexor digitorum profundus tendon injury,” The Journal of Bone and Joint Surgery American, vol. 95, no. 7, article e41, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. W. Lee, S. C. Fu, T. Y. Mok, K. M. Chan, and L. K. Hung, “Local administration of trolox, a vitamin E analog, reduced tendon adhesion in a chicken model of flexor digitorum profundus tendon injury,” Journal of Orthopaedic Translation, 2016. View at Publisher · View at Google Scholar
  10. L. M. Wong, Y. W. Lee, S.-C. Fu, K. M. Chan, and A. F. T. Mak, “Effect of oxidative stress on proliferation and differentiation of tendon derived stem cells,” British Journal of Sports Medicine, vol. 48, Supplement 2, pp. A72–A73, 2014. View at Google Scholar
  11. W. Y. Lee, P. P. Lui, and Y. F. Rui, “Hypoxia-mediated efficient expansion of human tendon-derived stem cells in vitro,” Tissue Engineering Part A, vol. 18, no. 5-6, pp. 484–498, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Li and H. E. Schellhorn, “New developments and novel therapeutic perspectives for vitamin C,” The Journal of Nutrition, vol. 137, no. 10, pp. 2171–2184, 2007. View at Google Scholar
  13. B. van der Loo, M. Bachschmid, V. Spitzer, L. Brey, V. Ullrich, and T. F. Lüscher, “Decreased plasma and tissue levels of vitamin C in a rat model of aging: implications for antioxidative defense,” Biochemical and Biophysical Research Communications, vol. 303, no. 2, pp. 483–487, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. L. F. Quintanilha, T. Takami, Y. Hirose et al., “Canine mesenchymal stem cells show antioxidant properties against thioacetamide-induced liver injury in vitro and in vivo,” Hepatology Research, vol. 44, no. 10, pp. E206–E217, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. S. C. Fu, W. H. Cheng, Y. C. Cheuk et al., “Development of vitamin C irrigation saline to promote graft healing in anterior cruciate ligament reconstruction,” Journal of Orthopaedic Translation, vol. 1, no. 1, pp. 67–77, 2013. View at Publisher · View at Google Scholar
  16. J. H. Kim, S. Y. Song, S. G. Park, S. U. Song, Y. Xia, and J. H. Sung, “Primary involvement of NADPH oxidase 4 in hypoxia-induced generation of reactive oxygen species in adipose-derived stem cells,” Stem Cells and Development, vol. 21, no. 12, pp. 2212–2221, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Busletta, E. Novo, L. Valfre Di Bonzo et al., “Dissection of the biphasic nature of hypoxia-induced motogenic action in bone marrow-derived human mesenchymal stem cells,” Stem Cells, vol. 29, no. 6, pp. 952–963, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Li, Y. Deng, J. Feng, and W. Ye, “Oxidative preconditioning promotes bone marrow mesenchymal stem cells migration and prevents apoptosis,” Cell Biology International, vol. 33, no. 3, pp. 411–418, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Huang, H. J. Kim, E. J. Chang et al., “IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: implications for bone remodeling,” Cell Death and Differentiation, vol. 16, no. 10, pp. 1332–1343, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. M. H. Sejersen, P. Frost, T. B. Hansen, S. R. Deutch, and S. W. Svendsen, “Proteomics perspectives in rotator cuff research: a systematic review of gene expression and protein composition in human tendinopathy,” PloS One, vol. 10, no. 4, article e0119974, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. G. Kempka, H. J. Ahr, W. Rüther, and G. Schlüter, “Effects of fluoroquinolones and glucocorticoids on cultivated tendon cells in vitro,” Toxicology in Vitro, vol. 10, no. 6, pp. 743–754, 1996. View at Publisher · View at Google Scholar · View at Scopus