Research Article
A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β-Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity?
Table 1
Data reduction and refinement statistics of CBS p.P49L structure.
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Information in parenthesis refers to the last resolution shell. , where denotes multiplicity and the-th reflection . , where denotes multiplicity and j the j-th reflection . is as described previously [69]. , where and are the observed and calculated structure factors for reflection (), respectively. was calculated as but using only 5% of reflections randomly selected and omitted from refinement. MolProbity score provides a single number that represents the central MolProbity protein quality statistics; it is a log-weighted combination of Clashscore, Ramachandran not favored, and bad side-chain rotamers, giving one number that reflects the crystallographic resolution at which those values would be expected. |