Deficiency of the Purinergic Receptor 2X₇ Attenuates Nonalcoholic Steatohepatitis Induced by High-Fat Diet: Possible Role of the NLRP3 Inflammasome

Figure 1

NAFLD grading and staging. Hematoxylin and eosin staining of liver sections from representative animals ((a); original magnification 100x) and NAFLD (steatosis) grading (b) and staging (c) in NFD- and HFD-fed WT and Pr2x₇^−/− mice ( per group). P = portal area; CV = centrolobular vein. The box indicates mice fulfilling NASH criteria. versus WT mice. NAFLD = nonalcoholic fatty liver disease; NFD = normal-fat diet; HFD = high-fat diet; WT = wild type; Pr2x₇^−/− = knockout for purinergic receptor 2X₇ gene; NASH = nonalcoholic steatohepatitis.

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