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Oxidative Medicine and Cellular Longevity
Volume 2017 (2017), Article ID 9032792, 14 pages
https://doi.org/10.1155/2017/9032792
Research Article

Green Tea Polyphenols Ameliorate the Early Renal Damage Induced by a High-Fat Diet via Ketogenesis/SIRT3 Pathway

1Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
3Department of Nutrition and Food Hygiene, School of Public Health and Management, Binzhou Medical University, Yantai 264003, China
4Department of Hotel Management, Tourism University, Guilin 541000, China
5Department of Nutrition and Food Hygiene, Xinxiang Medical University, Xinxiang 453000, China
6Kecheng People’s Hospital, Quzhou 324000, China
7School of Nursing, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
8Department of Clinical Nutrition, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

Correspondence should be addressed to Xuezhi Zuo; nc.ude.umjt.hjt@7691ouZ and Chenjiang Ying; nc.ude.tsuh@jcgniy

Received 28 March 2017; Revised 12 May 2017; Accepted 25 May 2017; Published 26 July 2017

Academic Editor: Giuseppe Grosso

Copyright © 2017 Weijie Yi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1. Effects of CR on renal ketogenesis. CR group were treated with 30% calorie restriction of CON. CR+GTPs group were treated with 30% calorie restriction of CON with 200mg/kg.bw GTPs. (A) Western blot analysis of HMGCS2, SIRT3, ac-MnSOD, MnSOD and Nampt expression levels in the renal cortex. (B-E) Density analysis of renal HMGCS2, SIRT3, ac-MnSOD/MnSOD and Nampt. (F,G) β-hydroxybutyrate concentrations in the kidney and serum. (H) Total NAD level in the renal cortex. The data are represented as the mean±SD (n=5-6); *P<0.05 vs the control group and &P <0.05 vs the CR group.

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