Epigenetics and Oxidative Stress in Aging

Figure 1

Epigenetic mechanisms and oxidative stress (OS) related to aging. Oxidative stress caused by either endogenous or exogenous factors gives rise to increased levels of reactive oxygen species (ROS), mitochondria acting as a main source of production. Uncontrolled production of ROS is involved in aging and aging-related diseases. Besides, ROS is an activity-modulated factor of epigenetic machinery. Epigenetic changes, for instance, global reduction in DNA methylation or hypermethylation of specific genes, among others, are also linked with aging.