Oxidative Medicine and Cellular Longevity / 2017 / Article / Tab 2

Research Article

Low Glucose Concentrations Induce a Similar Inflammatory Response in Monocytes from Type 2 Diabetic Patients and Healthy Subjects

Table 2

Paired differences comparing IL-1β (a) and IL-10 (b) levels after monocyte incubation at different glucose concentrations, with (LPS+) or without (LPS) lipopolysaccharide stimulation.
(a)

IL-1β paired differences (pg/mL)Controls ()Controls ()Diabetic patients ()Diabetic patients ()
LPSLPS+LPSLPS+

G5 − G2.5−56 ± 17∗∗−94 ± 28∗∗−79 ± 32−171 ± 57∗∗
G20 − G53 ± 8−6 ± 10−8 ± 80.5 ± 9.6

(b)

IL-10 paired differences (pg/mL)Controls ()Controls ()Diabetic patients ()Diabetic patients ()
LPSLPS+LPSLPS+

G5 − G2.5−3 ± 1−5 ± 6−3 ± 229 ± 20
G20 − G50 ± 1−21 ± 4∗∗−2 ± 1−36 ± 9∗∗

G2.5: glucose 2.5 mmol/L; G5: glucose 5.0 mmol/L; G20: glucose 20 mmol/L. Data are mean ± SEM. Paired comparisons were obtained by changing one experimental variable at a time. Negative values indicate a higher IL-1β (a) and IL-10 (b) concentration in the latter condition considered. , . Student’s t-test for paired data indicating a significant change between the paired experimental conditions stated in the first column.

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