Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone)

<div>A hypothetical radical-scavenging mechanism of edaravone. Edaravone anion scavenges radicals (<svg height="14.6307pt" id="M11" style="vertical-align:-3.834001pt" version="1.1" viewbox="-0.0498162 -10.7967 12.6613 14.6307" width="12.6613pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M333 262C333 337 270 397 193 397S54 337 54 262S116 127 193 127S333 187 333 262Z" id="g54-74"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="385" vert-adv-y="385"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,4.015,.842)"><path d="M655 0V28C585 35 563 50 517 120C469 193 414 280 360 366C427 469 460 516 481 545C526 604 545 614 619 622V650H391V622C457 614 462 604 438 560C411 511 381 463 339 398C295 466 258 523 225 580C210 606 211 615 272 622V650H26V622C98 614 111 603 154 538C189 482 235 408 288 324C200 188 149 116 124 85C95 47 64 34 7 28V0H236V28C169 36 164 46 188 89C220 148 261 217 310 291C372 193 417 118 442 77C461 44 454 35 392 28V0H655Z" id="g121-86"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="654" vert-adv-y="654"></glyph.data></g></svg>) to produce anion bodies (X<sup>−</sup>) and edaravone radicals. The final product is 2-oxo-3-(phenylhydrazono)-butanoic acid (OPB), which is without oxidation power.</div>

Oxidative Medicine and Cellular Longevity

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Figure 1

Figure 1: Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone) 