Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone)

Figure 4

Protective effects of edaravone against NMDA-induced retinal damage. Edaravone scavenges NMDA-induced ROS and rescues NMDA-induced retinal ganglion cell death by inhibiting phosphorylated JNK, p38 (but not ERK), lipid peroxidation, and oxidative stress to DNA.