Review Article
The Role of Nrf2 in Cardiovascular Function and Disease
Figure 2
ROS-induced uncoupling of eNOS and the generation of O2•. Excess ROS induce the conversion of BH4 to BH2 with subsequent eNOS uncoupling and synthesis of O2• instead of NO. eNOS: endothelial nitric oxide synthase; ROS: reactive oxygen species; NO: nitric oxide; O2•: superoxide; BH4: tetrahydrobiopterin; BH2: dihydrobiopterin.