The Role of Nrf2 in Cardiovascular Function and Disease

Table 1

List of proteins that bind to and modulate the activity of Nrf2.

Gene	Function	Reference
KEAP1	Retention in cytoplasm and degradation	[15]
CDH1/CTNNB1	Enhances KEAP1 interaction	[66]
CRF1	Ubiquitination and degradation	[67]
ATF4	Activation of gene expression	[68]
BRG1	Selective activation of gene expression	[69]
CBP	Activation of gene expression	[58]
CHD6	Activation of gene expression	[56]
JUN	Activation of gene expression	[9]
MAFF	Heterodimer activates gene expression	[70]
MAFG	Heterodimer activates gene expression	[71]
MAFK	Heterodimer activates gene expression	[71]
PMF1	Activation of gene expression	[72]
RAC3/AIB1/SRC-3	Activation of gene expression	[57]
PKC	Phosphorylation increases nuclear translocation	[73, 74]
HDAC1/2/3	Repression of gene expression	[75]
MYC	Repression of gene expression	[76]
PPARG	Repression of gene expression	[77]
RXRα	Repression of gene expression	[61]
FYN	Phosphorylation and nuclear export	[52]
SRC	Phosphorylation and nuclear export	[53]
YES	Phosphorylation and nuclear export	[53]