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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 9251303, 12 pages
Research Article

Arsenite Effects on Mitochondrial Bioenergetics in Human and Mouse Primary Hepatocytes Follow a Nonlinear Dose Response

1Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
2Department of Clinical Biochemistry, Christian Medical College, Vellore 632004, India
3Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA

Correspondence should be addressed to Partha Krishnamurthy; ude.cmuk@irutsakp

Received 15 September 2016; Revised 10 November 2016; Accepted 20 November 2016; Published 9 January 2017

Academic Editor: Rodrigo Franco

Copyright © 2017 Hemantkumar Chavan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Arsenic exposure did not affect cellular ATP levels significantly. suggesting that the increased oxygen consumption in response to low dose arsenite exposure was not a result of increased coupling efficiency. Interestingly, when oligomycin was added to inhibit oxidative phosphorylation to measure coupling efficneicny, primary hepatocytes demonstrated increased leak respiration suggesting increased uncoupling of respiration.

  1. Supplementary Material