Apocynin Prevents Abnormal Megakaryopoiesis and Platelet Activation Induced by Chronic Stress

Figure 4

Modifications of circulating cells induced by chronic stressed are reduced by Apocynin treatment. Numbers of circulating (a) leukocytes and (b) platelets were counted, and (c) platelet size and (d) percentage of reticulated platelets were analysed by flow cytometry in control mice exposed to forced swimming stress (FSS) and treatment with or without Apocynin (FSS + Apocynin). mice/group. , , and . For each box-plot, the center line illustrates the median and box limits indicate the 25th and 75th percentiles. Data were analyzed by the Kruskal-Willis test followed by a Dunn’s multiple comparison test.

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