Research Article
Mitochondria-Targeted Antioxidant SkQ1 Prevents Anesthesia-Induced Dry Eye Syndrome
Table 2
Pathomorphological characteristics of the cornea in general anesthesia-induced DES.
| Corneal compartment | Diagnosis | Parameter | Anesthesia time, h | Control | 1 | 3 | 6 |
| Epithelium | Superficial cell desquamation | Incidence, % | 0 | 100 | 100 | 100 | MSS | 0 | 2.3 ± 0.5 | 3.6 ± 0.6 | 4.3 ± 0.5 | Deep layer cell loss (erosion) | Incidence, % | 0 | 0 | 100 | 100 | MSS | 0 | 0 | 2.0 ± 0.9 | 4.3 ± 0.6 | Denudation | Incidence, % | 0 | 0 | 66 | 100 | MSS | 0 | 0 | 2.0 ± 1.5 | 4.0 ± 0.9 | Cell degeneration | Incidence, % | 0 | 0 | 100 | 100 | MSS | 0 | 0 | 3.3 ± 0.6 | 3.7 ± 0.5 | Signs of apoptosis | Incidence, % | 0 | 0 | 33 | 100 | MSS | 0 | 0 | 0.6 ± 0.9 | 3.6 ± 0.5 | Reepithelization | Incidence, % | 0 | 0 | 0 | 0 | MSS | 0 | 0 | 0 | 0 | Stroma | Edema | Incidence, % | 0 | 0 | 0 | 0 | MSS | 0 | 0 | 0 | 0 | Inflammatory infiltration | Incidence, % | 0 | 0 | 0 | 0 | MSS | 0 | 0 | 0 | 0 | Neovascularization | Incidence, % | 0 | 0 | 0 | 0 | MSS | 0 | 0 | 0 | 0 | Endothelium | Vacuolization | Incidence, % | 0 | 0 | 0 | 0 | MSS | 0 | 0 | 0 | 0 | Cell loss | Incidence, % | 0 | 0 | 0 | 0 | MSS | 0 | 0 | 0 | 0 |
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Incidence and mean severity scores (MSS) were determined as described in Materials and Methods. compared with control.
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