Antroquinonol Exerts Immunosuppressive Effect on CD8⁺ T Cell Proliferation and Activation to Resist Depigmentation Induced by H₂O₂

Figure 2

Effects of antroquinonol on cytokine production and T cell activation marker expression of CD8⁺ T cells. CD8⁺ T cells were stimulated with anti-CD3/anti-CD28 in the absence or presence of antroquinonol (20 μM) in a 24-well plate, and the culture supernatants were collected at 48 h for measuring the levels of IL-2 and IFN-γ by ELISA, and the expression of CD69 and CD137 by flow cytometry. Levels of IL-2 (a), IFN-γ (b), CD69 (c), and CD137 (d) in the antroquinonol-treated CD8⁺ T cells were less than those in the untreated CD8⁺ T cells. The values are presented as mean ± SD. (). means statistical difference.

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