Ginkgolide B Suppresses TLR4-Mediated Inflammatory Response by Inhibiting the Phosphorylation of JAK2/STAT3 and p38 MAPK in High Glucose-Treated HUVECs

Figure 6

Ginkgolide B inhibits JAK2 and STAT3 phosphorylation in LPS-treated HUVECs. The cells were treated with various concentrations of ginkgolide B for 1 h, and LPS was added for another 8 h. The column chart represents the density analysis from four independent experiments. (a) Ginkgolide B inhibited JAK2 phosphorylation that was induced by LPS. (b) Ginkgolide B inhibited STAT3 phosphorylation that was induced by LPS. (c) Stattic inhibited STAT3 phosphorylation that was induced by LPS. (d) The combination of ginkgolide B and stattic synergistically inhibited STAT3 phosphorylation that was induced by LPS. ^#, significant difference between non-LPS-treated cells and LPS-treated cells; , , significant difference between non-ginkgolide B-treated cells and ginkgolide B-treated cells.

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