Ginkgolide B Suppresses TLR4-Mediated Inflammatory Response by Inhibiting the Phosphorylation of JAK2/STAT3 and p38 MAPK in High Glucose-Treated HUVECs

Figure 7

Ginkgolide B inhibits p38 MAPK phosphorylation in high glucose-treated HUVECs. The cells were treated with various concentrations of ginkgolide B for 1 h, and glucose was added for another 8 h. The phosphorylation of p38 MAPK was analyzed by Western blot. The column chart represents the density analysis from four independent experiments. (a) Ginkgolide B inhibited p38 MAPK phosphorylation that was induced by high glucose. (b) SB203580 inhibited TLR4 expression that was induced by high glucose. (c) SB203580 inhibited PECAM-1 expression that was induced by high glucose. ^#, significant difference between nonhigh glucose-treated cells and high glucose-treated cells; , significant difference between non-ginkgolide B-treated cells and ginkgolide B-treated cells.

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